Table 1. Natural course of hyperphagia in Prader-Willi syndrome

Phases Median ages Clinical characteristics
0 Prenatal to birth Less activity during pregnancy and a smaller birth weight than siblings
1 At birth Hypotonia
1a 0−9 months Difficulty feeding and decreased appetite
1b 9−24 months Enhanced appetite and eating; proper growth
2a 2.0−4.5 years Gaining weight in the absence of an increase in appetite or additional calories
2b 4.5−8.0 years Heightened interest in and hunger for meals, but feeling full
3 8 years-adulthood Hyperphagic, rarely feels full
4 Adulthood Appetite is no longer insatiable